Large scale evaluation of differences between network-based and pairwise sequence-alignment-based methods of dendrogram reconstruction.

ABSTRACT: Dendrograms are a way to represent relationships between organisms. Nowadays, these are inferred based on the comparison of genes or protein sequences by taking into account their differences and similarities. The genetic material of choice for the sequence alignments (all the genes or sets of genes) results in distinct inferred dendrograms. In this work, we evaluate differences between dendrograms reconstructed with different methodologies and for different sets of organisms chosen at random from a much larger set. A statistical analysis is performed to estimate fluctuations between the results obtained from the different methodologies that allows us to validate a systematic approach, based on the comparison of the organisms' metabolic networks for inferring dendrograms. This has the adva

SUBMITTER: Gamermann D 

PROVIDER: S-EPMC6728023 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature