3D-Printed Biodegradable Microswimmer for Theranostic Cargo Delivery and Release.

ABSTRACT: Untethered mobile microrobots have the potential to leverage minimally invasive theranostic functions precisely and efficiently in hard-to-reach, confined, and delicate inner body sites. However, such a complex task requires an integrated design and engineering, where powering, control, environmental sensing, medical functionality, and biodegradability need to be considered altogether. The present study reports a hydrogel-based, magnetically powered and controlled, enzymatically degradable microswimmer, which is responsive to the pathological markers in its microenvironment for theranostic cargo delivery and release tasks. We design a double-helical architecture enabling volumetric cargo loading and swimming capabilities under rotational magnetic fields and a 3D-printed optimized 3D micros

SUBMITTER: Ceylan H 

PROVIDER: S-EPMC6728090 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature