Ontology highlight
ABSTRACT:
SUBMITTER: Griciuc A
PROVIDER: S-EPMC6728215 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Neuron 20190710 5
The microglial receptors CD33 and TREM2 have been associated with risk for Alzheimer's disease (AD). Here, we investigated crosstalk between CD33 and TREM2. We showed that knockout of CD33 attenuated amyloid beta (Aβ) pathology and improved cognition in 5xFAD mice, both of which were abrogated by additional TREM2 knockout. Knocking out TREM2 in 5xFAD mice exacerbated Aβ pathology and neurodegeneration but reduced Iba1<sup>+</sup> cell numbers, all of which could not be rescued by additional CD33 ...[more]