Mouse Models for Studying Oral Cancer: Impact in the Era of Cancer Immunotherapy.

ABSTRACT: Model systems for oral cancer research have progressed from tumor epithelial cell cultures to in vivo systems that mimic oral cancer genetics, pathological characteristics, and tumor-stroma interactions of oral cancer patients. In the era of cancer immunotherapy, it is imperative to use model systems to test oral cancer prevention and therapeutic interventions in the presence of an immune system and to discover mechanisms of stromal contributions to oral cancer carcinogenesis. Here, we review in vivo mouse model systems commonly used for studying oral cancer and discuss the impact these models are having in advancing basic mechanisms, chemoprevention, and therapeutic intervention of oral cancer while highlighting recent discoveries concerning the role of immune cells in oral cancer. Improv

SUBMITTER: Luo JJ 

PROVIDER: S-EPMC6728551 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature