A High-Resolution Map of SBP1 Interactomes in Plasmodium falciparum-infected Erythrocytes.

ABSTRACT: The pathogenesis of malaria parasites depends on host erythrocyte modifications that are facilitated by parasite proteins exported to the host cytoplasm. These exported proteins form a trafficking complex in the host cytoplasm that transports virulence determinants to the erythrocyte surface; this complex is thus essential for malaria virulence. Here, we report a comprehensive interaction network map of this complex. We developed authentic, unbiased, highly sensitive proteomic approaches to determine the proteins that interact with a core component of the complex, SBP1 (skeleton-binding protein 1). SBP1 interactomes revealed numerous exported proteins and potential interactors associated with SBP1 intracellular trafficking. We identified several host-parasite protein interactions and linke

SUBMITTER: Takano R 

PROVIDER: S-EPMC6728614 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature