Stroke atlas of the brain: Voxel-wise density-based clustering of infarct lesions topographic distribution.

ABSTRACT:

Objective

The supply territories of main cerebral arteries are predominantly identified based on distribution of infarct lesions in patients with large arterial occlusion; whereas, there is no consensus atlas regarding the supply territories of smaller end-arteries. In this study, we applied a data-driven approach to construct a stroke atlas of the brain using hierarchical density clustering in large number of infarct lesions, assuming that voxels/regions supplied by a common end-artery tend to infarct together.

Methods

A total of 793 infarct lesions on MRI scans of 458 patients were segmented and coregistered to MNI-152 standard brain space. Applying a voxel-wise data-driven hierarchical density clustering algorithm, we identified those voxels that were most likely to be pa

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6728875 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature