BRCA mutations in a cohort of Iraqi patients presenting to a tertiary referral center.

ABSTRACT:

Background

Unique pathogenic mutations in BRCA1 and 2 genes have been reported in different populations of patients originating from the Middle East region. Limited data are available for the Iraqi population. For many reasons a large number of Iraqi patients present to Lebanon for medical care. This is the first report of BRCA full gene sequencing conducted in a cohort of high-risk patients originating from Iraq.

Methods

This is a retrospective review of Iraqi patients diagnosed with breast or ovarian cancer referred for BRCA mutation testing at the American University of Beirut from January 2012 to October 2018.

Results

Of the 42 Iraqi women who underwent genetic testing at our institution, 3 BRCA pathogenic variants were found. Two mutations in BRCA1 c.224_227delAA

SUBMITTER: Farra C 

PROVIDER: S-EPMC6728935 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature