Evidence for the association between <i>FTO</i> gene variants and vitamin B12 concentrations in an Asian Indian population.

ABSTRACT:

Background

Low vitamin B12 concentrations have been associated with major clinical outcomes, including adiposity, in Indian populations. The Fat mass and obesity-associated gene (FTO) is an established obesity-susceptibility locus; however, it remains unknown whether it influences vitamin B12 status. Hence, we investigated the association of two previously studied FTO polymorphisms with vitamin B12 concentrations and metabolic disease-related outcomes and examined whether these associations were modified by dietary factors and physical activity.

Methods

A total of 176 individuals with type 2 diabetes, 152 with pre-diabetes, and 220 normal glucose-tolerant individuals were randomly selected from the Chennai Urban Rural Epidemiology Study. Anthropometric, clinica

SUBMITTER: Surendran S 

PROVIDER: S-EPMC6728975 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature