Most of anti-glycolipid IgG-antibodies associated to neurological disorders occur without their IgM counterpart.

ABSTRACT:

Background

Different neurological disorders frequently display antibodies against several self-glycans. Increasing evidence supports their pathogenic role; however, far less is known about their origin. Meanwhile, antibodies recognizing non-self glycans appear in normal human serum during immune response to bacteria.

Methods

Using high performance thin layer chromatography-immunostaining, we comparatively evaluated humoral immune response (IgG and IgM immunoreactivity) against glycolipids carrying self-glycans (GM3/GM2/GM1/GD1a/GD1b/GD3/GT1b/GQ1b) and non-self glycans (Forssman/GA1/"A" blood group/Nt7) in sera from 383 patients with neurological disorders along with 87 healthy controls.

Results

In contrast to no healthy controls having anti-self glycan IgG antibodies,

SUBMITTER: Lardone RD 

PROVIDER: S-EPMC6729026 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature