Deciphering DNA methylation signatures of pancreatic cancer and pancreatitis.

ABSTRACT: BACKGROUND:Chronic pancreatitis presents a high risk of inflammation-related progression to pancreatic cancer. Pancreatic cancer is the fourth leading cause of cancer-related death worldwide. The high mortality rate is directly related to the difficulty in promptly diagnosing the disease, which often presents as overt and advanced. Hence, early diagnosis for pancreatic cancer becomes crucial, propelling research into the molecular and epigenetic landscape of the disease. MAIN BODY:Recent studies have shown that cell-free DNA methylation profiles from inflammatory diseases or cancer can vary, thus opening a new venue for the development of biomarkers for early diagnosis. In particular, cell-free DNA methylation could be employed in the identification of pre-neoplastic signatures in individu

SUBMITTER: Natale F 

PROVIDER: S-EPMC6729090 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature