CT-Based Radiomics Signature for the Preoperative Discrimination Between Head and Neck Squamous Cell Carcinoma Grades.

ABSTRACT: Background: Radiomics has been widely used to non-invasively mine quantitative information from medical images and could potentially predict tumor phenotypes. Pathologic grade is considered a predictive prognostic factor for head and neck squamous cell carcinoma (HNSCC) patients. A preoperative histological assessment can be important in the clinical management of patients. We applied radiomics analysis to devise non-invasive biomarkers and accurately differentiate between well-differentiated (WD) and moderately differentiated (MD) and poorly differentiated (PD) HNSCC. Methods: This study involved 206 consecutive HNSCC patients (training cohort: n = 137; testing cohort: n = 69). In total, we extracted 670 radiomics features from contrast-enhanced computed tomography (CT) images. Radiomics

SUBMITTER: Wu W 

PROVIDER: S-EPMC6729100 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature