The Association of Iron and the Pathologies of Parkinson's Diseases in MPTP/MPP⁺-Induced Neuronal Degeneration in Non-human Primates and in Cell Culture.

ABSTRACT: Despite much efforts in the last few decades, the mechanism of degeneration of dopamine (DA) neurons in the substantia nigra (SN) in Parkinson's disease (PD) remains unclear. This represents a major knowledge gap in idiopathic and genetic forms of PD. Among various possible key factors postulated, iron metabolism has been widely suggested to be involved with fueling oxidative stress, a known factor in the pathogenesis of PD. However, the correlation between iron and DA neuron loss, specifically in the SN, has not been described in experimental animal models with great detail, with most studies utilizing rodents and, rarely, non-human primates. In the present study, aiming to gain further evidence of a pathological role of iron in PD, we have examined the correlation of iron with DA neuron

SUBMITTER: Shi L 

PROVIDER: S-EPMC6729105 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature