Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin.

ABSTRACT:

Rationale

Respiratory tract infections are common in patients suffering from pulmonary fibrosis. The interplay between bacterial infection and fibrosis is characterised poorly.

Objectives

To assess the effect of Gram-positive bacterial infection on fibrosis exacerbation in mice.

Methods

Fibrosis progression in response to Streptococcus pneumoniae was examined in two different mouse models of pulmonary fibrosis.

Measurements and main results

We demonstrate that wild-type mice exposed to adenoviral vector delivery of active transforming growth factor-β1 (TGFß1) or diphteria toxin (DT) treatment of transgenic mice expressing the DT receptor (DTR) under control of the surfactant protein C (SPC) promoter (SPC-DTR) to induce pulmonary fibrosis developed progressive f

SUBMITTER: Knippenberg S 

PROVIDER: S-EPMC6729139 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature