Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors.

ABSTRACT: Autoimmunity to membrane proteins in the central nervous system has been increasingly recognized as a cause of neuropsychiatric disease. A key recent development was the discovery of autoantibodies to N-methyl-d-aspartate (NMDA) receptors in some cases of encephalitis, characterized by cognitive changes, memory loss, and seizures that could lead to long-term morbidity or mortality. Treatment approaches and experimental studies have largely focused on the pathogenic role of these autoantibodies. Passive antibody transfer to mice has provided useful insights but does not produce the full spectrum of the human disease. Here, we describe a de novo autoimmune mouse model of anti-NMDA receptor encephalitis. Active immunization of immunocompetent mice with conformationally stabilized, native-like

SUBMITTER: Jones BE 

PROVIDER: S-EPMC6729143 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature