Type VI Secretion System in Pathogenic Escherichia coli: Structure, Role in Virulence, and Acquisition.

ABSTRACT: Bacterial pathogens utilize a myriad of mechanisms to invade mammalian hosts, damage tissue sites, and evade the immune system. One essential strategy of Gram-negative bacteria is the secretion of virulence factors through both inner and outer membranes to reach a potential target. Most secretion systems are harbored in mobile elements including transposons, plasmids, pathogenicity islands, and phages, and Escherichia coli is one of the more versatile bacteria adopting this genetic information by horizontal gene transfer. Additionally, E. coli is a bacterial species with members of the commensal intestinal microbiota and pathogens associated with numerous types of infections such as intestinal, urinary, and systemic in humans and other animals. T6SS cluster plasticity suggests evolutionari

SUBMITTER: Navarro-Garcia F 

PROVIDER: S-EPMC6730261 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature