Risk of Nephrotic Syndrome for Non-Steroidal Anti-Inflammatory Drug Users.

ABSTRACT:

Background and objectives

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with AKI. Their association with nephrotic syndrome has not been systematically studied. This study aimed to assess the risk of nephrotic syndrome associated with NSAID use.

Design, setting, participants, & measurements

A matched case-control study was performed in the UK primary care database. Cases were patients with a first diagnosis of nephrotic syndrome and controls were those without nephrotic syndrome. NSAID exposure (grouped either based on cyclooxygenase enzyme selectivity and chemical groups) was classified as either current (use at the nephrotic syndrome diagnosis date and corresponding date in the control group), recent, or past use. Odds ratios (ORs) and 95% confidence i

SUBMITTER: Bakhriansyah M 

PROVIDER: S-EPMC6730525 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature