Identification of Aloperine as an anti-apoptotic Bcl2 protein inhibitor in glioma cells.

ABSTRACT:

Objective

Aloperine (ALO), an alkaloid isolated from the leaves of Sophora alopecuroides, has been suggested to exhibit anti-inflammatory and anti-tumor properties and is traditionally used to treat various human diseases, including cancer. However, limited information is available about the mechanisms that determine the anti-tumor activities of ALO.

Methods

Herein, through comprehensive bioinformatics methods and in vitro functional analyses, we evaluated the detailed anti-tumor mechanisms of ALO.

Results

Using the databases Bioinformatics analysis tool for molecular mechanism of traditional Chinese medicine and PubChem Project, we identified the potential targets of ALO. A protein-protein interaction network was constructed to determine the relationship among

SUBMITTER: Xu Z 

PROVIDER: S-EPMC6730530 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature