The seizure onset zone drives state-dependent epileptiform activity in susceptible brain regions.

ABSTRACT:

Objective

Due to variability in the patterns of propagation of interictal epileptiform discharges (IEDs), qualitative definition of the irritative zone has been challenging. Here, we introduce a quantitative approach toward exploration of the dynamics of IED propagation within the irritative zone.

Methods

We examined intracranial EEG (iEEG) in nine participants undergoing invasive monitoring for seizure localization. We used an automated IED detector and a community detection algorithm to identify populations of electrodes exhibiting IED activity that co-occur in time, and to group these electrodes into communities.

Results

Within our algorithmically-identified communities, IED activity in the seizure onset zone (SOZ) tended to lead IED activity in other functionally

SUBMITTER: Diamond JM 

PROVIDER: S-EPMC6730646 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature