Protective Innate Immune Variants in Racial/Ethnic Disparities of Breast and Prostate Cancer.

ABSTRACT: Individuals of African descent are disproportionately affected by specific complex diseases, such as breast and prostate cancer, which are driven by both biological and nonbiological factors. In the case of breast cancer, there is clear evidence that psychosocial factors (environment, socioeconomic status, health behaviors, etc.) have a strong influence on racial disparities. However, even after controlling for these factors, overall phenotypic differences in breast cancer pathology remain among groups of individuals who vary by geographic ancestry. There is a growing appreciation that chronic/reoccurring inflammation, primarily driven by mechanisms of innate immunity, contributes to core functions associated with cancer progression. Germline mutations in innate immune genes that have been

SUBMITTER: Yeyeodu ST 

PROVIDER: S-EPMC6730653 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature