Multidimensional Predictors of Susceptibility and Resilience to Social Defeat Stress.

ABSTRACT:

Background

Previous studies identified several separate risk factors for stress-induced disorders. However, an integrative model of susceptibility versus resilience to stress including measures from brain-body domains is likely to yield a range of multiple phenotypic information to promote successful adaptation to stress.

Methods

We used computational and molecular approaches to test whether 1) integrative brain-body behavioral, immunological, and structural domains characterized and predicted susceptibility or resilience to social defeat stress (SDS) in mice and 2) administration of acetyl-L-carnitine promoted resilience at the SDS paradigm.

Results

Our findings identified multidimensional brain-body predictors of susceptibility versus resilience to SDS. The copresen

SUBMITTER: Nasca C 

PROVIDER: S-EPMC6730655 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature