Effects of a carrier's sex and age on the segregation patterns of the trivalent of Robertsonian translocations.

ABSTRACT:

Purpose

To investigate the effects of a carrier's sex and age on the segregation patterns of the trivalent of Robertsonian translocations.

Methods

This retrospective study was designed to analyze the segregation patterns of the trivalent and euploidy rates of blastocysts. Data were collected from 154 couples with Robertsonian translocation (77 with a female carrier and 77 with a male carrier). Embryos were diagnosed via array comparative genomic hybridization between January 2013 and July 2017. The segregation patterns of the trivalent of 604 blastocysts were analyzed according to the carrier's sex and age.

Results

The proportion of alternate segregation was significantly higher (82.9% vs. 55.2%) in the male carriers than in the female carriers of Robertsonian translo

SUBMITTER: Zhang L 

PROVIDER: S-EPMC6730718 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature