Comparison of oral versus parenteral methotrexate in the treatment of rheumatoid arthritis: A meta-analysis.

ABSTRACT: OBJECTIVE:Studies suggest that parenteral MTX may be more efficacious than the oral form at equivalent doses for the treatment of rheumatoid arthritis. We carried out a meta-analysis to compare the efficacy of oral versus parenteral MTX in RA. METHODS:PubMed, Web of Science and Embase were systematically searched from inception to June 8th 2017 and reviewed following PRISMA 2009 guidelines, by two independent reviewers. To be included, trials had to study adults with RA randomized to the same dose of either oral or parenteral MTX. The primary endpoint was ACR20 at 6 months. Intention-to-treat analysis results were used when possible. Data from direct comparisons between oral and parenteral methotrexate quantitatively analyzed using maximum likelihood random effects meta-analysis. Relative

SUBMITTER: Bujor AM 

PROVIDER: S-EPMC6731021 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature