Covalent Poly(lactic acid) Nanoparticles for the Sustained Delivery of Naloxone.

ABSTRACT: The opioid epidemic currently plaguing the United States has been exacerbated by an alarming rise in fatal overdoses as a result of the proliferated abuse of synthetic mu opioid receptor (MOR) agonists, such as fentanyl and its related analogues. Attempts to manage this crisis have focused primarily on widespread distribution of the clinically approved opioid reversal agent naloxone (Narcan); however, due to the intrinsic metabolic lability of naloxone, these measures have demonstrated limited effectiveness against synthetic opioid toxicity. This work reports a novel polymer-based strategy to create a long-acting formulation of naloxone with the potential to address this critical issue by utilizing covalent nanoparticle (cNP) drug delivery technology. Covalently loaded naloxone nanoparticl

SUBMITTER: Kassick AJ 

PROVIDER: S-EPMC6731033 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature