Associations of the Fecal Microbial Proteome Composition and Proneness to Diet-induced Obesity.

ABSTRACT: Consumption of refined high-fat, low-fiber diets promotes development of obesity and its associated consequences. Although genetics play an important role in dictating susceptibility to such obesogenic diets, mice with nearly uniform genetics exhibit marked heterogeneity in their extent of obesity in response to such diets. This suggests non-genetic determinants play a role in diet-induced obesity. Hence, we sought to identify parameters that predict, and/or correlate with, development of obesity in response to an obesogenic diet. We assayed behavior, metabolic parameters, inflammatory markers/cytokines, microbiota composition, and the fecal metaproteome, in a cohort of mice (n = 50) prior to, and the 8 weeks following, administration of an obesogenic high-fat low-fiber diet. Neithe

SUBMITTER: Tran HQ 

PROVIDER: S-EPMC6731084 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature