In Vitro and In Vivo Evaluation of the Anticancer and Anti-inflammatory Activities of 2-Himachelen-7-ol isolated from Cedrus Libani.

ABSTRACT: Cedrus libani is a majestic evergreen tree native to the Mediterranean mountains of Lebanon, Syria and Turkey. In this study, the tree heart wood was extracted using hexane to produce C. libani oil extract (CLOE) as a dark oil. GCMS analysis of CLOE identified up to 30 compounds whereby 2-himachalen-7-ol (7-HC) was the most abundant (40%). 7-HC was isolated using column chromatography and the identity of the white crystalline solid was confirmed via NMR spectroscopy and X-Ray Crystallography. 7-HC demonstrated potent cytotoxic activity against several human cancer cell lines including brain (SF-268, IC₅₀ 8.1 μg/mL) and colon (HT-29, IC₅₀ 10.1 μg/mL; Caco-2, IC₅₀ 9.9 μg/mL) with ovarian (Sk-OV-3, IC₅₀ > 50 μg/mL) cells being the most resistant. Ho

SUBMITTER: Elias A 

PROVIDER: S-EPMC6731217 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature