Extracellular vesicle-coupled miRNA profiles in follicular fluid of cows with divergent post-calving metabolic status.

ABSTRACT: Most high-yielding dairy cows enter a state of negative energy balance (NEB) during early lactation. This, in turn, results in changes in the level of various metabolites in the blood and follicular fluid microenvironment which contributes to disturbed fertility. Extracellular vesicles (EVs) are evolutionarily conserved communicasomes that transport cargo of miRNA, proteins and lipids. EV-coupled miRNAs have been reported in follicular fluid. However, the association between postpartum NEB and EV-coupled miRNA signatures in follicular fluid is not yet known. Energy balance analysis in lactating cows shortly after post-calving revealed that the majority of the cows exhibited transiently negative energy balance levels, whereas the remaining cows exhibited either consistently negative or cons

SUBMITTER: Hailay T 

PROVIDER: S-EPMC6731312 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature