Registry Kinetics of Myosin Motor Stacks Driven by Mechanical Force-Induced Actin Turnover.

ABSTRACT: Actin filaments associated with myosin motors constitute the cytoskeletal force-generating machinery for many types of adherent cells. These actomyosin units are structurally ordered in muscle cells and, in particular, may be spatially registered across neighboring actin bundles. Such registry or stacking of myosin filaments have been recently observed in ordered actin bundles of even fibroblasts with super-resolution microscopy techniques. We introduce here a model for the dynamics of stacking arising from long-range mechanical interactions between actomyosin units through mutual contractile deformations of the intervening cytoskeletal network. The dynamics of registry involve two key processes: 1) polymerization and depolymerization of actin filaments and 2) remodeling of cross-linker-ri

SUBMITTER: Dasbiswas K 

PROVIDER: S-EPMC6731391 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature