Vitamin B5 inhibit RANKL induced osteoclastogenesis and ovariectomy induced osteoporosis by scavenging ROS generation.

ABSTRACT: B vitamins are a class of water-soluble vitamins that play important roles in cell metabolism. The participation of B vitamins in bone health has been recognized for decades. Pantothenic acid (vitamin B5) is mainly known for its wide variety of sources. However, the potential role of pantothenic acid in bone health and metabolism is still unclear. In this study, we found pantothenic acid has a dual effect on RANKL-induced osteoclastogenesis. Tartrate-resistant acid phosphatase (TRAP) stain shows that osteoclastogenesis was remarkably induced in a lower dosage of pantothenic acid (< 200 mM) and significantly inhibited while the pantothenic acid concentration increases to a certain extent (> 500 mM). We further confirmed this dual effect of pantothenic acid in osteoclastogenesis by detecting

SUBMITTER: Ma Q 

PROVIDER: S-EPMC6731427 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature