The first report of molecular characterized BRD4-NUT carcinoma in Brazil: a case report.

ABSTRACT:

Background

NUT midline carcinoma is a rare and aggressive subset of squamous cell carcinoma, which is characterized by the translocation of nuclear protein in testis gene that is mostly fused with bromodomain and extraterminal family proteins. We describe here the first Brazilian case of NUT midline carcinoma with BRD4-NUT fusion detected in a next-generation sequencing panel and we present the clinical evolution of this patient.

Case presentation

A 42-year-old Caucasian man was diagnosed with poorly differentiated squamous cell carcinoma of the left maxillary sinus, with negative in situ hybridization for Epstein-Barr encoding region and human papillomavirus genotyping. He received induction therapy, chemoradiotherapy with weekly systemic chemotherapy, and, concurrently, we

SUBMITTER: Oliveira LJC 

PROVIDER: S-EPMC6731562 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature