A novel evolutionary model for constructing gene coexpression networks with comprehensive features.

ABSTRACT:

Background

Uncovering the evolutionary principles of gene coexpression network is important for our understanding of the network topological property of new genes. However, most existing evolutionary models only considered the evolution of duplication genes and only based on the degree of genes, ignoring the other key topological properties. The evolutionary mechanism by which how are new genes integrated into the ancestral networks are not yet to be comprehensively characterized. Herein, based on the human ribonucleic acid-sequencing (RNA-seq) data, we develop a new evolutionary model of gene coexpression network which considers the evolutionary process of both duplication genes and de novo genes.

Results

Based on the human RNA-seq data, we construct a gene coexpression net

SUBMITTER: Gu Y 

PROVIDER: S-EPMC6731579 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature