Center effect in intubation risk in critically ill immunocompromised patients with acute hypoxemic respiratory failure.

ABSTRACT: BACKGROUND:Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients, and the need for invasive mechanical ventilation has become a major clinical endpoint in randomized controlled trials (RCTs). However, data are lacking on whether intubation is an objective criteria that is used unbiasedly across centers. This study explores how this outcome varies across ICUs. METHODS:Hierarchical models and permutation procedures for testing multiple random effects were applied on both data from an observational cohort (the TRIAL-OH study: 703 patients, 17 ICUs) and a randomized controlled trial (the HIGH trial: 776 patients, 31 ICUs) to characterize ICU variation in intubation risk across centers. RESULTS:The crude intubation rate varied acro

SUBMITTER: Dumas G 

PROVIDER: S-EPMC6731598 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature