Genetic variants in Forkhead box O1 associated with predisposition to sepsis in a Chinese Han population.

ABSTRACT:

Background

Genetic variant is one of the causes of sepsis patients' mortality. Now, many studies have identified several SNPs related to sepsis. However, none of these studies were identified in a genome-wide way. We aimed to detect genetic polymorphisms of sepsis patients.

Methods

The blood samples of eight normal controls and ten sepsis patients were collected for whole exome sequencing. Then, Single Nucleotide Polymorphisms (SNPs) were selected according to quality score and number of sepsis patients who had this variants. Synonymous mutations were removed. Genes including these remaining variants were used for functional analyses. After analyses, the remaining SNPs and indels were validated in 149 normal controls and 156 sepsis patients. Finally, serum levels of proteins

SUBMITTER: Wang H 

PROVIDER: S-EPMC6731606 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature