A high-throughput system to identify inhibitors of Candidatus Liberibacter asiaticus transcription regulators.

ABSTRACT: Citrus greening disease, also known as huanglongbing (HLB), is the most devastating disease of Citrus worldwide. This incurable disease is caused primarily by the bacterium Candidatus Liberibacter asiaticus and spread by feeding of the Asian Citrus Psyllid, Diaphorina citriCa L. asiaticus cannot be cultured; its growth is restricted to citrus phloem and the psyllid insect. Management of infected trees includes use of broad-spectrum antibiotics, which have disadvantages. Recent work has sought to identify small molecules that inhibit Ca L. asiaticus transcription regulators, based on a premise that at least some regulators control expression of genes necessary for virulence. We describe a synthetic, high-throughput screening system to identify compounds th

SUBMITTER: Barnett MJ 

PROVIDER: S-EPMC6731658 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature