The iron-regulated vacuolar Legionella pneumophila MavN protein is a transition-metal transporter.

ABSTRACT: Legionella pneumophila causes a potentially fatal form of pneumonia by replicating within macrophages in the Legionella-containing vacuole (LCV). Bacterial survival and proliferation within the LCV rely on hundreds of secreted effector proteins comprising high functional redundancy. The vacuolar membrane-localized MavN, hypothesized to support iron transport, is unique among effectors because loss-of-function mutations result in severe intracellular growth defects. We show here an iron starvation response by L. pneumophila after infection of macrophages that was prematurely induced in the absence of MavN, consistent with MavN granting access to limiting cellular iron stores. MavN cysteine accessibilities to a membrane-impermeant label were determined during macrophage

SUBMITTER: Christenson ET 

PROVIDER: S-EPMC6731752 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature