Mechanistic insights into nitrite-induced cardioprotection using an integrated metabolomic/proteomic approach.

ABSTRACT: Nitrite has recently emerged as an important bioactive molecule, capable of conferring cardioprotection and a variety of other benefits in the cardiovascular system and elsewhere. The mechanisms by which it accomplishes these functions remain largely unclear. To characterize the dose response and corresponding cardiac sequelae of transient systemic elevations of nitrite, we assessed the time course of oxidation/nitros(yl)ation, as well as the metabolomic, proteomic, and associated functional changes in rat hearts following acute exposure to nitrite in vivo. Transient systemic nitrite elevations resulted in: (1) rapid formation of nitroso and nitrosyl species; (2) moderate short-term changes in cardiac redox status; (3) a pronounced increase in selective manifestations of long-term oxidativ

SUBMITTER: Perlman DH 

PROVIDER: S-EPMC6731772 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature