FOXN3 hyperglycemic risk allele and insulin sensitivity in humans.

ABSTRACT: Objective:The rs8004664 variation within the FOXN3 gene is significantly and independently associated with fasting blood glucose in humans. We have previously shown that the hyperglycemia risk allele (A) increases FOXN3 expression in primary human hepatocytes; over-expression of human FOXN3 in zebrafish liver increases fasting blood glucose; and heterozygous deletion of the zebrafish ortholog foxn3 decreases fasting blood glucose. Paralleling these model organism findings, we found that rs8004664 A|A homozygotes had blunted glucagon suppression during an oral glucose tolerance test. Here, we test associations between insulin sensitivity and the rs8004664 variation. Research design and methods:92 participants (49±13 years, body mass index: 32±6 kg/m2, 28 with and 64 without type 2 diabetes

SUBMITTER: Erickson ML 

PROVIDER: S-EPMC6731827 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature