Neonatal azithromycin administration to prevent infant mortality: study protocol for a randomised controlled trial.

ABSTRACT:

Introduction

Biannual mass azithromycin distribution to children aged 1-59 months has been shown to reduce all-cause mortality. Children under 28 days of age were not treated in studies evaluating mass azithromycin distribution for child mortality due to concerns related to infantile hypertrophic pyloric stenosis (IHPS). Here, we report the design of a randomised controlled trial to evaluate the efficacy and safety of administration of a single dose of oral azithromycin during the neonatal period.

Methods and analysis

The Nouveaux-nés et Azithromycine: une Innovation dans le Traitement des Enfants (NAITRE) study is a double-masked randomised placebo-controlled trial designed to evaluate the efficacy of a single dose of azithromycin (20 mg/kg) for the prevention of chi

SUBMITTER: Sie A 

PROVIDER: S-EPMC6731835 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature