Cost-effectiveness of selective digestive decontamination (SDD) versus selective oropharyngeal decontamination (SOD) in intensive care units with low levels of antimicrobial resistance: an individual patient data meta-analysis.

ABSTRACT:

Objective

To determine the cost-effectiveness of selective digestive decontamination (SDD) as compared to selective oropharyngeal decontamination (SOD) in intensive care units (ICUs) with low levels of antimicrobial resistance.

Design

Post-hoc analysis of a previously performed individual patient data meta-analysis of two cluster-randomised cross-over trials.

Setting

24 ICUs in the Netherlands.

Participants

12 952 ICU patients who were treated with ≥1 dose of SDD (n=6720) or SOD (n=6232).

Interventions

SDD versus SOD.

Primary and secondary outcome measures

The incremental cost-effectiveness ratio (ICER; ie, costs to prevent one in-hospital death) was calculated by comparing differences in direct healthcare costs and in-hospital mortality of patien

SUBMITTER: van Hout D 

PROVIDER: S-EPMC6731916 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature