Leg ischaemia management collaboration (LIMb): study protocol for a prospective cohort study at a single UK centre.

ABSTRACT:

Introduction

Severe limb ischaemia (SLI) is the end stage of peripheral arterial occlusive disease where the viability of the limb is threatened. Around 25% of patients with SLI will ultimately require a major lower limb amputation, which has a substantial adverse impact on quality of life. A newly established rapid-access vascular limb salvage clinic and modern revascularisation techniques may reduce amputation rate. The aim of this study was to investigate the 12-month amputation rate in a contemporary cohort of patients and compare this to a historical cohort. Secondary aims are to investigate the use of frailty and cognitive assessments, and cardiac MRI in risk-stratifying patients with SLI undergoing intervention and establish a biobank for future biomarker analyses.

Method

SUBMITTER: Houghton JSM 

PROVIDER: S-EPMC6731919 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature