Non-monotonic dose-response effects of arsenic on glucose metabolism.

ABSTRACT:

Background

Inorganic arsenic (iAs) is a widespread environmental toxin. In addition to being a human carcinogen, its effect on diabetes has started to gain recognition recently. Insulin is the key hormone regulating systemic glucose metabolism. The in vivo effect of iAs on insulin sensitivity has not been directly addressed.

Objectives

Here we use mouse models to dissect the dose-dependent effects of iAs on glucose metabolism in vivo.

Methods

We performed hyperinsulinemic-euglycemic clamp, the gold standard analysis of systemic insulin sensitivity. We also performed dynamic metabolic testings and RNA-seq analysis.

Results

We found that a low-dose exposure (0.25 ppm iAs in drinking water) caused glucose intolerance in adult male C57BL/6 mice, likely by disruptin

SUBMITTER: Gong Y 

PROVIDER: S-EPMC6731945 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature