STAT gene family mRNA expression and prognostic value in hepatocellular carcinoma.

ABSTRACT:

Background

Signal transducer and activator of transcription (STAT) proteins are well-known transcription factors that play an important role in the progression of cancer. However, the association between STAT family genes and hepatocellular carcinoma (HCC) remains unclear. This study investigates the expression level, the prognostic value and the potential mechanism of STAT family genes in HCC.

Methods

Data from 365 HCC patients in The Cancer Genome Atlas (TCGA) database and 241 HCC patients in the Gene Expression Omnibus (GEO) database were used to investigate the diagnostic and prognostic values of STAT genes by survival analysis and nomogram. Gene set enrichment analysis (GSEA) was used to investigate the potential mechanism of the STAT genes in the development of HCC.

SUBMITTER: Dong Z 

PROVIDER: S-EPMC6731967 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature