Distinct Molecular Trajectories Converge to Induce Naive Pluripotency.

ABSTRACT: Understanding how cell identity transitions occur and whether there are multiple paths between the same beginning and end states are questions of wide interest. Here we show that acquisition of naive pluripotency can follow transcriptionally and mechanistically distinct routes. Starting from post-implantation epiblast stem cells (EpiSCs), one route advances through a mesodermal state prior to naive pluripotency induction, whereas another transiently resembles the early inner cell mass and correspondingly gains greater developmental potency. These routes utilize distinct signaling networks and transcription factors but subsequently converge on the same naive endpoint, showing surprising flexibility in mechanisms underlying identity transitions and suggesting that naive pluripotency is a mul

SUBMITTER: Stuart HT 

PROVIDER: S-EPMC6731995 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature