White Matter Hyperintensities and Hippocampal Atrophy in Relation to Cognition: The 90+ Study.

ABSTRACT:

Objectives

To study the interactive effect of white matter hyperintensities (WMH) and hippocampal atrophy on cognition in the oldest old.

Design

Ongoing longitudinal study.

Setting

In Southern California, brain magnetic resonance imaging (MRI) scans were conducted between May 2014 and December 2017.

Participants

Individuals from The 90+ Study with a valid brain MRI scan (N = 141; 94 cognitively normal and 47 with cognitive impairment).

Measurements

Cognitive testing was performed every 6 months with a mean follow-up of 2 years and included these tests: Mini-Mental State Examination (MMSE), modified MMSE (3MS), California Verbal Learning Test (CVLT) immediate recall over four trials and delayed recall, Digit Span Backward, Animal Fluency, and Trail Making

SUBMITTER: Legdeur N 

PROVIDER: S-EPMC6732042 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature