Exogenous progesterone for smoking cessation in men and women: a pilot double-blind, placebo-controlled randomized clinical trial.

ABSTRACT:

Background and aims

In some clinical studies men and women have been found to differ in their ability to quit smoking, perhaps as a result of progesterone. The primary aim of this study was to provide a preliminary test of whether progesterone (PRO), compared with placebo (PBO), was more effective for smoking cessation in men and women.

Design

Pilot double-blind, placebo-controlled randomized clinical trial.

Setting

Minneapolis/St Paul metro area, Minnesota, USA.

Participants

A total of 216 participants were randomized, including 113 men (18-60 years; PRO = 56, PBO = 57) and 103 women (18-50 years, pre-menopausal with self-reported regular menstrual cycles; PRO = 51, PBO = 52).

Intervention

Participants were randomized (1 : 1 within sex group) to either

SUBMITTER: Tosun NL 

PROVIDER: S-EPMC6732045 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature