Cortical activation in generalized seizures.

ABSTRACT:

Objective

Patients with generalized epilepsy exhibit different epileptiform events including asymptomatic interictal spikes (IS), absence seizures with spike-wave discharges (SWDs), and myoclonic seizures (MS). Our objective was to determine the spatiotemporal patterns of cortical activation in SWDs, IS, and MS in the Gabra1^+/A322D juvenile myoclonic epilepsy mouse.

Methods

We fabricated affordable, flexible high-density electroencephalography (HdEEG) arrays and recorded spontaneous SWD, IS, and MS with video/HdEEG. We determined differences among the events in amplitude spectral density (ASD) in the δ/θ/α/β/γ frequency bands at baseline (3.5-4.0 seconds before the first spike time, t₀ ) and the prespike period (0.1-0.5 seconds before t₀ ), a

SUBMITTER: Ding L 

PROVIDER: S-EPMC6732052 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature