Mice heterozygous for the Cdh23/Ahl1 mutation show age-related deficits in auditory temporal processing.

ABSTRACT: A mutation in the Cdh23 gene is implicated in both syndromic and nonsyndromic hearing loss in humans and age-related hearing loss in C57BL/6 mice. It is generally assumed that human patients (as well as mouse models) only have a hearing loss phenotype if the mutation is homozygous. However, a major complaint for patients with a hearing disability is a reduced speech intelligibility that may be related to temporal processing deficits rather than just elevated thresholds. In this study, we used the amplitude modulation following response (AMFR) to test whether mice heterozygous for Cdh23735A > G have an auditory phenotype that includes temporal processing deficits. The hearing of mice heterozygous for the Cdh23735A > G mutation was compared with age-matched mice homozygous for either the mut

SUBMITTER: Burghard AL 

PROVIDER: S-EPMC6732241 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature