Association of single nucleotide polymorphisms of miRNAs involved in the GLUT4 pathway in T2DM in a Chinese population.

ABSTRACT:

Background

The insulin/insulin receptor substrate (IRS)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/GLUT4 pathway plays a crucial role in insulin resistance and is closely associated with T2DM. Accumulating evidence indicates that miRNAs (such as miR-135a, let-7d, miR-107, miR-96, miR-29a, miR-23a, miR-126, miR-133a, and miR-106b) influence the GLUT4 pathway.

Methods

A total of 784 subjects with T2DM and 846 nondiabetic subjects were enrolled and 12 single nucleotide polymorphisms (SNPs) in miRNAs (rs10459194 in miR-135a-2, rs10993081 and rs7045890 in let-7d, rs2296616 in miR-107, rs2402959 and rs6965643 in miR-96, rs24168 in miR-29a, rs3745453 in miR-23a, rs4636297 in miR-126, rs8089787 and rs9948906 in miR-133a-1 and rs999885 in miR-106b) involved in the GL

SUBMITTER: Li Y 

PROVIDER: S-EPMC6732275 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature