Relationships between SNPs and prognosis of breast cancer and pathogenic mechanism.

ABSTRACT:

Background

Association between several single-nucleotide polymorphisms (SNPs) and breast cancer risk has been identified through genome-wide association studies (GWAS), but little is known about their significance in patients' prognosis. We screened SNPs which were related to the prognosis of breast cancer in Henan Han population, analyzed relevant genes by bioinformatics in database, and further constructed the genetic regulatory network involved in the pathogenesis of breast cancer.

Methods

We evaluated five SNPs in 232 cases of breast cancer at the Affiliated Tumor Hospital of Zhengzhou University. Relationships between five SNPs, clinical prognostic indicators, and disease-free survival (DFS) were evaluated by Kaplan-Meier analysis and Cox proportional hazards model. Gen

SUBMITTER: He Y 

PROVIDER: S-EPMC6732281 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature