Impact of CHRNA5 polymorphisms on the risk of schizophrenia in the Chinese Han population.

ABSTRACT:

Background

Schizophrenia is a complex mental disease whose cause is still unknown. Neuronal nicotinic acetylcholine receptors (nAChRs) have been implicated in various neurological disorders, including schizophrenia. The previous reports have shown that CHRNA polymorphisms were involved in schizophrenia. This study is to explore the potential association between CHRNA5 (OMIM#118505) polymorphisms and schizophrenia susceptibility in a Chinese population.

Methods and results

A case-control study was conducted with 384 schizophrenia patients and 687 controls. We genotyped eight single nucleotide polymorphisms (SNPs) distributed in CHRNA5. Regulome DB, HaploReg, and GTEx databases were used to calculate possible functional effects of the polymorphisms. The χ² test, gen

SUBMITTER: Zhan D 

PROVIDER: S-EPMC6732284 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature