Evolutionary history of disease-susceptibility loci identified in longitudinal exome-wide association studies.

ABSTRACT:

Background

Our longitudinal exome-wide association studies previously detected various genetic determinants of complex disorders using ~26,000 single-nucleotide polymorphisms (SNPs) that passed quality control and longitudinal medical examination data (mean follow-up period, 5 years) in 4884-6022 Japanese subjects. We found that allele frequencies of several identified SNPs were remarkably different among four ethnic groups. Elucidating the evolutionary history of disease-susceptibility loci may help us uncover the pathogenesis of the related complex disorders.

Methods

In the present study, we conducted evolutionary analyses such as extended haplotype homozygosity, focusing on genomic regions containing disease-susceptibility loci and based on genotyping data of our previous

SUBMITTER: Yasukochi Y 

PROVIDER: S-EPMC6732299 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature